Bioinformatic strategies in metagenomics of chronic prostatitis.

ABSTRACT:

Purpose

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological condition in young men, significantly affecting quality of life due to persistent discomfort and neuropsychological symptoms. Despite its high prevalence, the etiology of CP/CPPS remains poorly understood. This study investigated urinary microbiota differences between CP/CPPS patients and healthy controls to identify microbial contributors, antibiotic resistance genes (ARGs), and virulence factors of dominant bacteria, as well as to explore potential therapeutic targets.

Methods

Urine samples were collected from 58 CP/CPPS patients and 25 controls. Symptom severity was assessed by a specialist urologist using the NIH Chronic Prostatitis Symptom Index and UPOINT classification. Bacter

SUBMITTER: Davasaz Tabrizi E 

PROVIDER: S-EPMC11947071 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature