Brain functional and structural alteration following acute carbon monoxide poisoning contribute to delayed neurological sequelae.

ABSTRACT:

Purpose

To investigate whether altered functional activity, functional connectivity (FC), and structural connectivity (SC) following acute carbon monoxide (CO) poisoning contribute to delayed neurological sequelae (DNS) occurrence.

Methods

Binary degree centrality (DC) and seed-based FC were investigated in 18 patients with DNS, 26 patients without DNS, and 30 healthy controls. Duration of CO exposure and coma severity indices-related fibers was detected by connectometry analysis and the identified fiber tracts were tracked and their SC alteration was quantify by fractional anisotropy (FA).

Results

Acute CO exposure induced DC change in the prefrontal cortex (PFC), visual cortex, primary sensory cortex, and anterior cerebellum, and FC alteration between the right fusi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11947078 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature