Nomogram to predict progression from preserved ratio impaired spirometry to chronic obstructive pulmonary disease.

ABSTRACT: Preserved Ratio Impaired Spirometry (PRISm) is a specific subtype of pre-chronic obstructive pulmonary disease (pre-COPD). People with PRISm are at risk of progression to chronic obstructive pulmonary disease (COPD). We developed a model to predict progression in subjects with PRISm. We screened 188 patients whose lung function transitioned from PRISm to COPD and 173 patients with PRISm who remained stable over two years. After excluding 78 patients due to incomplete clinical or laboratory data, a total of 283 patients were included in the final analysis. These patients were randomly divided into a training cohort (227 patients) and a validation cohort (56 patients) at a 8:2 ratio. LASSO regression and multivariate logistic regression were used to identify factors influencing progression.

SUBMITTER: Wu J 

PROVIDER: S-EPMC11947084 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature