Phase dependent sympathetic dysinnervation in Takotsubo syndrome revealed with transparent heart.

ABSTRACT: Takotsubo syndrome (TTS) is an acute cardiac syndrome characterized by transient left ventricular dysfunction. Although the wall motion abnormality resolves completely, the prognosis is poor. Defect of ¹²³I-metaiodobenzylguanidine uptake, interpreted as sympathetic impairment, persisted in TTS patients, but the mechanism is not fully understood. We aimed to elucidate morphological sympathetic nerve change in a TTS model mouse using three-dimensional imaging techniques, with a particular focus on the role of factors in these alterations. The TTS model was induced by a single intraperitoneal injection of 2.0 mg/kg adrenaline to C57BL/6 mice, resulting in transient akinesis localized to the inferior apical region of the heart. Three-dimensional morphological assessment revealed tha

SUBMITTER: Masuyama K 

PROVIDER: S-EPMC11947107 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature