Single-cell transcriptomics reveals inter-ethnic variation in immune response to Falciparum malaria.

ABSTRACT: Africa's environmental, cultural, and genetic diversity can profoundly shape population responses to infectious diseases, including malaria caused by Plasmodium falciparum. Differences in malaria susceptibility among populations are documented, but the underlying mechanisms remain poorly understood. Notably, the Fulani ethnic group in Africa is less susceptible to malaria compared to other sympatric groups, such as the Mossi. They exhibit lower disease rates and parasite load as well as enhanced serological protection. However, elucidating the molecular and cellular basis of this protection has been challenging in part due to limited immunological characterization at the cellular level. To address this question, we performed single-cell transcriptomic profiling of peripheral blood mononucl

SUBMITTER: Shahin T 

PROVIDER: S-EPMC11947175 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature