The lifelong nonlinear development of spatial variability of brain signals.

ABSTRACT: The physiological information carried by brain signals is distinguished by their mean and variability. Research has indicated that both the variability of local signals and the spatial mean of the whole-brain signal (known as the global signal, GS) are sensitive to brain development. This raises the question of whether the spatial variability of the whole-brain signal, referred to as global variability (GV), could potentially serve as a more specific marker of brain development. We first established the reliability of GV and its topography (GVtopo) using data from the Human Connectome Project (HCP). Then, we examined the age-related patterns of GV and GVtopo in the Nathan Kline Institute Rockland Sample (NKI-RS; N = 968, ages ranging from 6 to 85 years) and validated these findings in an i

SUBMITTER: Yang C 

PROVIDER: S-EPMC11947206 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature