Regional quantification of metabolic liver function using hyperpolarized [1-¹³C] pyruvate MRI.

ABSTRACT: Assessment of liver function is essential before partial hepatectomy to predict the risk of post hepatectomy liver failure, a severe and life-threatening complication. Traditional methods have focused on expected future liver remnant (FLR) volume estimation. However, liver volume does not always correlate with function. We suggest that metabolism might be a better surrogate for function than volume. Therefore, we aimed to investigate the metabolic changes in a porcine model of partial portal vein ligation (PVL) using hyperpolarized magnetic resonance imaging (HP-MRI). Specifically, we sought to quantify and compare the pyruvate metabolism in the FLR and the deportalized liver (DL).Six pigs underwent PVL. HP-MRI with [1-¹³C] pyruvate was performed at baseline, post-surgery, and 1

SUBMITTER: Kjaergaard U 

PROVIDER: S-EPMC11947255 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature