Loss of fatty acid-binding protein 7 promotes B16F10 melanoma metastasis.

ABSTRACT: Melanoma possesses the characteristic phenotypic plasticity, enhancing its metastatic formation and drug resistance. Lipid and fatty acid metabolism are usually altered to support melanoma progression and can be targeted for therapeutic development. Fatty acid binding protein 7 (FABP7) is highly expressed in melanomas and is shown to support its proliferation, migration, and invasion, but the mechanisms remain unclear. Our study aimed to link FABP7 to lipid metabolism and phenotypic shift in melanomas. We established the Fabp7-knockout (KO) B16F10 melanoma cells, which showed an enhanced invasion through matrix-coated membrane, without significant change in proliferation. Similar outcomes were obtained when using RNA interference targeting FABP7. Fabp7-KO cells injected into mice exhibited

SUBMITTER: Wannakul T 

PROVIDER: S-EPMC11947267 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature