Multi-omics integration identifies molecular markers and biological pathways for carcass and meat quality traits in Nellore cattle.

ABSTRACT: Understanding the biological factors that influence carcass and meat quality traits in Nellore cattle requires a clear interpretation of molecular complexity and its variations at different levels of expression. Hence, this study aimed to elucidate the biological control of carcass and meat quality traits in Nellore cattle by integrating genome-wide association study (GWAS), transcriptomic, and proteomic data, focusing on identifying key genes and pathways. GWAS analysis was performed using weighted single-step GBLUP with two iterations. RNA-Seq and proteomic analyses were performed on 24 muscle samples from animals with divergent adjusted phenotypic values (12 for high and 12 for low), for meat tenderness, ribeye area (REA), marbling, and backfat thickness (BFT). The phenotypic values wer

SUBMITTER: Frezarim GB 

PROVIDER: S-EPMC11947269 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature