Wearable-derived short sleep duration is associated with higher C-reactive protein in a placebo-controlled vaccine trial among young adults.

ABSTRACT: Inadequate sleep has been associated with an increased risk of mortality and various health issues. We previously conducted a placebo-controlled vaccination trial of healthy adults who were monitored by blood samples, questionnaires, and wearable devices. C-reactive protein (CRP), a systemic marker of inflammation, has been linked to numerous health outcomes, and was found to significantly increase post-vaccination in the trial. In this retrospective study, we investigated that if sleep was associated with an inflammation response triggered by perturbations from vaccine and placebo injections. Plasma hs-CRP levels were measured on the same day as the intervention, prior to the vaccine/placebo administration and two days after the intervention. Associations of sleep duration and CRP levels

SUBMITTER: Wang C 

PROVIDER: S-EPMC11947287 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature