Revisiting the Relationship Between Tumor Size and Risk in Well-Differentiated Thyroid Cancer.

ABSTRACT: Introduction: Large tumor size is associated with poorer outcomes in well-differentiated thyroid cancer, yet it remains unclear whether size >4 cm alone confers increased risk, independent of other markers of aggressive disease. The goal of this study was to assess the relationship between tumor size, other high-risk histopathological features, and survival in well-differentiated thyroid cancer and to evaluate the significance of 4 cm as a cutoff for management decisions. Methods: Patients with well-differentiated thyroid cancer were identified from the National Cancer Database (2010-2015) and categorized by tumor size (i.e., small [≤4 cm] or large [>4 cm]) and presence of high-risk histopathological features (e.g., extrathyroidal extension). First, propensity s

SUBMITTER: Ginzberg SP 

PROVIDER: S-EPMC11947635 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature