Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort.

ABSTRACT:

Introduction

Amyloid positron emission tomography (PET) is increasingly available for diagnosis of Alzheimer`s disease (AD); however, its practical implications in heterogenous cohorts are debated.

Methods

Amyloid PET from 890 National Alzheimer`s Coordinating Center participants with up to 10 years post-PET follow up was analyzed. Cox proportional hazards and linear mixed models were used to investigate amyloid burden prediction of etiology and prospective functional status and cognitive decline.

Results

Amyloid positivity was associated with progression from unimpaired to mild cognitive impairment and dementia. Amyloid burden in the unimpaired group was associated with lower initial memory levels and faster decline in memory, language, and global cognition. In the I

SUBMITTER: Younes K 

PROVIDER: S-EPMC11947745 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature