The Fe-Cyclam-Derived Compound [Fe(cyclam)sal]PF₆ Restrains Drug-Resistant <i>Staphylococcus aureus</i> Proliferation and Biofilm Formation.

ABSTRACT: Staphylococcus aureus is a bacterium found on the skin and mucous membranes of humans and animals. This micro-organism is classified as an opportunistic pathogen and causes infections in both hospital and community settings. The increase in antibiotic resistance, especially methicillin-resistant S. aureus (MRSA), is a major challenge for clinical and epidemiological practice. The present study aims to investigate the potential antibacterial and antibiofilm activities of the compound [Fe(cyclam)sal]PF6 against drug-resistant strains of S. aureus. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) against S. aureus strains ATCC 25904, S. aureus ATCC 33591, and S. aureus 05-0052 were determined for [Fe(cyclam)s

SUBMITTER: Branca MT 

PROVIDER: S-EPMC11947776 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature