Design and Synthesis of Novel Di-Boronic Acid-Based Chemical Glucose Sensors.

ABSTRACT: Chemical-based fluorescent sensors with the capability of long-term stability and low cost are promising agents in clinical diagnosis and medical research. Measuring glucose levels inside cells and their surroundings provides insight into cellular metabolic homeostasis and may be employed as an indicator for potential pathological conditions. Anthracene-based diboronic acid (BA) derivatives offer a reversible and covalent binding mechanism for glucose recognition, which enables robust and continuous glucose monitoring. To improve its poor solubility and biological applicability, a diboronic acid chemical structure design was explored. To date, several anthracene-based ortho-amino methylphenyl boronic acid glucose-sensors have been developed. Most recently, the structure of Mc-CDBA (((((2-(

SUBMITTER: Goldberg D 

PROVIDER: S-EPMC11947836 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature