Preparation of Temperature-Sensitive Molecularly Imprinted Cryogel for Specific Recognition of Proteins.

ABSTRACT: In order to maintain the stability of the structure of protein molecules and improve the recognition during the separation process, molecular imprinting technology is combined with freeze polymerization to synthesize molecular imprinting cryogels (MICs). This study uses bovine serum albumin (BSA) as a template protein, low critical cosolubility temperature (LCST)-type ionic liquids as temperature-sensitive functional monomers, imidazole ionic liquids, and acrylamides as auxiliary functional monomers to prepare MICs with specific recognition, temperature sensitivity, interpenetrating macroporous structure, and large specific surface area. The MICs prepared at freezing temperature have uniform macroporous structures and good mechanical properties, which is conducive to the improvement of the

SUBMITTER: Cheng D 

PROVIDER: S-EPMC11947846 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature