Lower tidal volume ventilation post-bilateral lung transplantation is associated with ventilator-free days.

ABSTRACT:

Background

There is limited evidence regarding the effect of invasive mechanical ventilation practice post-bilateral lung transplantation. Invasive mechanical ventilation practice may be associated with prolonged ventilation, particularly when referenced to donor anthropometrics.

Methods

This was a single-centre retrospective cohort study that included consecutive adult bilateral lung transplant recipients between 2015 and 2021 who were ventilated for a minimum of 24 h post-surgery. Lower and higher tidal volume sub-groups were defined for mean and maximum values indexed to both donor and recipient predicted body weight over the first 72 h. The primary outcome was ventilator-free days in the first 28 days, and this was analysed using the Wilcoxon rank sum test and a competin

SUBMITTER: Morgan S 

PROVIDER: S-EPMC11947859 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature