Association Between Early Heparin Prophylaxis and Risk of Venous Thromboembolism Through Two Months After Spine Fusion for Spinal Metastasis: A Retrospective Cohort Study of United States Academic Health Centers.

ABSTRACT: Study DesignRetrospective Cohort Study.ObjectiveEvidence on chemoprophylactic anticoagulation efficacy in preventing venous thromboembolism (VTE) after spine surgery for metastasis is scarce. We hypothesized that early heparin administration (0-2 days post-surgery) significantly reduces VTE risk post-arthrodesis. We also examined VTE incidence and risk over 2 months and severe postoperative bleeding (SPOB).MethodsWe conducted a retrospective cohort study using the TriNetX network, identifying adults who had a spinal arthrodesis for spinal metastasis in the past 20 years. Patients were grouped by anticoagulation use: a heparin cohort and a non-anticoagulated control. After propensity matching for key VTE risk factors, we examined VTE risk ratios (RR) with 95% confidence intervals (CI) up to

SUBMITTER: Baumann AN 

PROVIDER: S-EPMC11948240 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature