Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice.

ABSTRACT: Temporomandibular joint (TMJ) pain and osteoarthritis (OA) are common and debilitating disorders that impair patients' quality of life. The mechanisms driving diseases-related pain are poorly understood, and current treatments fail to provide effective and long-term therapeutic effects. Additionally, pain assessment in research, particularly orofacial pain, poses several challenges that complicate studies in both clinical and basic science settings. Therefore, we have established an inflammatory TMJ pain mouse model via intra-articular injection of CFA (Complete Freund's Adjuvant) and evaluated pain behaviors by bite force measurement and the von Frey filament test. Mice with CFA injection exhibited orofacial pain behaviors compared to PBS injection, including reduced bite force and head w

SUBMITTER: Jariyasakulroj S 

PROVIDER: S-EPMC11948272 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature