Exploring the dermal safety of green-synthesized Ag-TiO₂ nanocomposites for topical applications.

ABSTRACT: We investigated Ag-TiO₂ nanocomposites (NCs) synthesized using leaf extracts of Azadirachta indica and Mangifera indica for topical applications. The Ag-TiO₂ NCs were first characterized by their spherical shapes, with sizes ranging from 20-26 nm to 5-6 nm, and a zeta potential value between -27 and -23 mV. DLS analysis revealed average particle sizes of 671 nm and 573 nm for Ag-TiO₂ NCs synthesized from A. indica and M. indica, respectively. The MICs of the nanocomposites were determined via dilution in both Gram-positive and Gram-negative bacteria to determine the optimal concentration for dermal applications. The cytotoxicity assay (MTT) of ATN and ATM compounds at MICs of 312.5 μg mL^-1, 625 μg mL^-1

SUBMITTER: Rana A 

PROVIDER: S-EPMC11948306 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature