Prion Partitioning and Persistence in Environmental Waters.

ABSTRACT: Chronic wasting disease (CWD) is a fatal neurodegenerative disease affecting cervids. CWD is caused by infectious prions, which can enter the environment through bodily fluids or the carcasses of infected animals. Prions can be stored, remain infectious in both soil and water for many years, and transported hydrologically, possibly expanding the geographic range of CWD transmission. In order to better predict hydrological prion transport, we investigated how CWD prion protein (PrP^CWD) partitions and persists in environmental waters. We performed PrP^CWD spike experiments with water samples containing fine sediments from two locations within a CWD-contaminated site, at which contamination sources were removed one year prior. Samples were filtered after spiking, and filt

SUBMITTER: Li EA 

PROVIDER: S-EPMC11948337 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature