Effects of adjunctive milrinone versus placebo on hemodynamics in patients with septic shock: a randomized controlled trial.

ABSTRACT:

Background

Refractory septic shock can lead to multiorgan failure and death due to myocardial dysfunction-induced inadequate tissue perfusion. Current guidelines advocate inotropic adjuncts to norepinephrine, but the efficacy of milrinone remains understudied in this context. This study aimed to evaluate the hemodynamic changes in septic shock patients treated with adjunctive milrinone compared to those treated with a placebo.

Methods

This multicenter, double-blind, randomized controlled trial enrolled adults with septic shock, adequate fluid resuscitation, and a mean arterial pressure ≥ 65 mmHg. Eligible patients exhibited poor tissue perfusion or impaired left ventricular systolic function. Participants were randomized 1:1 to milrinone or placebo. Echocardiographic hemodyn

SUBMITTER: Tongyoo S 

PROVIDER: S-EPMC11948359 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature