ITGA3-MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways.

ABSTRACT:

Background

Studies have examined the role of integrin α3 (ITGA3) in papillary thyroid carcinoma (PTC). However, the functional and molecular mechanism by which ITGA3 is involved in the progression of PTC remains poorly understood.

Methods

To investigate the role of ITGA3 in PTC, raw PTC transcriptome data underwent comprehensive bioinformatics analyses, including differential expression, co-expression network, and enrichment analyses. ITGA3 expression was validated via immunohistochemistry and western blotting in PTC tissues. Cell functional assays and xenograft models assessed PTC cell behaviour. The potential mechanisms of ITGA3 were elucidated using bioinformatics analyses, western blotting, co-immunoprecipitation, and immunofluorescence. Finally, integration of IT

SUBMITTER: Lan Y 

PROVIDER: S-EPMC11948363 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature