Fat-separated T1 mapping for liver function analysis on gadoxetic acid-enhanced MR imaging: 2D two-point Dixon Look-Locker inversion recovery sequence for differentiation of Child-Pugh class B/C from Child-Pugh class A/chronic liver disease.

ABSTRACT:

Background

T1 relaxation time is a tissue-specific parameter that correlates with liver fibrosis, and can be a valuable tool for detecting and staging of liver disease. However, T1 can be affected by histological factors such as fat, so it is necessary to study the effects of hepatic steatosis when assessing liver function and fibrosis. The purpose of this study is to investigate the fat separation effect of T1 mapping using Dixon watermap Look-Locker inversion recovery (LLIR) in the assessment of liver function on gadoxetic acid (GA)-enhanced magnetic resonance imaging (MRI).

Methods

A total of 226 patients who underwent 3T MRI, including a 2D Dixon fat-separated LLIR T1 mapping, were included retrospectively. Two independent readers measured pre- and post-contrast T1 relax

SUBMITTER: Hwang YR 

PROVIDER: S-EPMC11948398 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature