Diagnostic value of miR‑21 and miR‑221 as potential biomarkers for early diagnosis of prostate cancer.

ABSTRACT: Prostate cancer (PCa) is globally the second most diagnosed malignancy in men, with >1.5 million new cases reported in 2020. Given the limitations of classical detection methods, the discovery of new predictive PCa biomarkers is critical. MicroRNAs (miRs), which are small, single-stranded, non-coding RNA molecules, have emerged as potential biomarkers for cancer diagnosis and prognosis. The present study aimed to evaluate the diagnostic value of miR-21 and miR-221 in PCa and their association with clinicopathological parameters. The expression of miR-21 and miR-221 was assessed using reverse transcription-quantitative PCR in 50 tumour and 50 control tissue samples. The results demonstrated that miR-21 and miR-221 were significantly upregulated in PCa tissues compared with that of the norma

SUBMITTER: Mharrach I 

PROVIDER: S-EPMC11948486 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature