Investigator-initiated versus industry-sponsored trials - visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT).

ABSTRACT:

Background

The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this to be possible, studies such as randomized controlled trials (RCTs), which are widely considered to provide the best evidence of all forms of primary research, must be visible and have an impact on clinical practice guidelines. We further investigated the impact of publicly and commercially sponsored RCTs on clinical practice guidelines by measuring direct and indirect impactful citations and the time to guideline impact.

Methods

We considered the sample from the IMPACT study, where a total of 691 RCTs (120 German investigator-initiated trials (IITs), 200 international IITs, 171 German industry-sponsored trials (ISTs) and 200 international IST

SUBMITTER: Hecht M 

PROVIDER: S-EPMC11948659 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature