Associations of combined lifestyle and metabolic risks with cancer incidence in the UK biobank study.

ABSTRACT:

Background

Although metabolic syndrome (MetS) is associated with an increased risk of various cancers, the combined impact of MetS and healthy lifestyle factors (HLF) on cancer risk is unclear. This study aimed to investigate the independent and combined effects of MetS and HLF on the risk of 16 site-specific cancers in a large community-based cohort.

Methods

A total of 289,557 participants in the UK Biobank were analyzed. MetS was defined using a combination of metabolic factors, while HLF scores were evaluated based on lifestyle behaviors, such as smoking, alcohol consumption, physical activity, and diet. Cox proportional hazard models were used to investigate the relationship between MetS or HLF and cancer risk, adjusting for age, sex, ethnicity, education level, family h

SUBMITTER: Lin F 

PROVIDER: S-EPMC11948676 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature