Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I.

ABSTRACT:

Background

Linker histones constitute a class of proteins that are responsible for the formation of higher-order chromatin structures. Core histones are integral components of nucleosome core particles (NCPs), whereas linker histones bind to linker DNA between NCPs. Heterochromatin protein 1 binding protein 3 (HP1BP3) displays sequence similarity to linker histones, with the exception of the presence of three globular domains in its central region. However, the function of HP1BP3 as a linker histone has not been analyzed previously. The present study aimed to elucidate the function of full-length HP1BP3 as a linker histone variant.

Results

The results of biochemical analyses demonstrate that HP1BP3 efficiently binds to NCPs with similar efficiency as linker histones, thereby

SUBMITTER: Hisaoka M 

PROVIDER: S-EPMC11948679 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature