Frequency-specific modulation of motor cortical excitability by transcranial alternating current stimulation.

ABSTRACT:

Background

Transcranial alternating current stimulation (tACS) is a non-invasive technique that modulates neural oscillations, yet its specific effects on cortical excitability are not well-understood. This study investigated the effects of tACS on neuroplasticity in the primary motor cortex (M1) across different frequencies.

Methods

In this randomized, sham-controlled, crossover study, 18 healthy young adults received β-tACS γ-tACS, and sham stimulation over the M1. Neurophysiological responses were assessed using motor evoked potentials (MEPs), electroencephalograms (EEG), and transcranial evoked potentials (TEPs) to determine the frequency-specific effects of tACS on cortical excitability and neuroplasticity.

Results

γ-tACS significantly enhanced cortical excitabil

SUBMITTER: Tingting L 

PROVIDER: S-EPMC11948692 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature