Diagnostic performance of plasma p-tau217 in a memory clinic cohort using the Lumipulse automated platform.

ABSTRACT:

Background

Plasma biomarkers for Alzheimer's disease (AD) are a promising tool for accessible and accurate biological diagnostics. However, data in clinical practice are needed to better understand their diagnostic and prognostic ability in memory unit patients.

Methods

We analyzed plasma phosphorylated tau at threonine 217 (p-tau217) and neuroflament light chain (NfL) levels and AD cerebrospinal fluid (CSF) biomarkers in a group of 493 subjects using the Lumipulse G600II platform. The sample includes 340 patients from our memory unit (142 dementia, 186 mild cognitive impairment, and 12 with subjective complaints) and 153 cognitively unimpaired volunteers. We have correlated plasma and CSF biomarkers; we have analyzed plasma biomarker levels as a function of clinical diagnos

SUBMITTER: Martinez-Dubarbie F 

PROVIDER: S-EPMC11948696 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature