The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor.

ABSTRACT:

Background

Transcription factor 4 (TCF4) is a member of the basic helix-loop-helix (bHLH) family of transcription factors that guides proper embryogenesis, particularly neurogenesis, myogenesis, heart development and hematopoiesis. The interaction of TCF4 with DNA is dependent on the presence of a conserved bHLH domain, particularly the presence of a basic (b) motif. Most mutations in the Tcf4 gene are either associated with the development of serious nervous system disorders, such as Pitt-Hopkins syndrome or schizophrenia, or are lethal. Although TCF4 is essential for the proper development and function of the human body, there is a lack of fundamental knowledge about the structure of TCF4 since structural studies were previously limited exclusively to its bHLH.

Methods

Rec

SUBMITTER: Sozanska N 

PROVIDER: S-EPMC11948756 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature