Treatment and control of Haemaphysalis longicornis infestations on dogs using a formulation of sarolaner, moxidectin and pyrantel (Simparica Trio®).

ABSTRACT:

Background

Simparica Trio^® (Zoetis), an orally administered combination product for dogs containing sarolaner, moxidectin and pyrantel pamoate, was evaluated against Haemaphysalis longicornis, a tick species originally native to Asia but now found on multiple continents, including North America.

Methods

Two groups of eight dogs each were ranked based on pretreatment tick counts and then allocated through randomization to treatment on Day 0 with a single dose of either placebo or Simparica Trio at the minimum label dose of 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt). Dogs were infested with 50 viable adult H. longicornis on Days -2, 5, 12, 19, 26 and 33. Tick counts were conducted for all dogs 48 h after treatment and subsequent

SUBMITTER: Kryda K 

PROVIDER: S-EPMC11948799 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature