Comparison of the diagnostic and prognostic value of criteria for immune checkpoint inhibitor related myocarditis.

ABSTRACT:

Background

Myocarditis is a dreaded complication of immune-checkpoint inhibitor (ICI) therapy but challenging to diagnose. There are no published data comparing the two leading diagnostic criteria for ICI-related myocarditis (ICIrM) and their association with cardiovascular events.

Methods

In this retrospective cohort study, we reviewed all patients who underwent ICI therapy and had cardiac troponin assessment for possible myocarditis across three tertiary institutions from 2011 to 2022. ICIrM was adjudicated by the Bonaca et al. criteria and the ESC-ICOS guidelines. A propensity matched control group was identified of patients treated with ICI without developing myocarditis. Baseline characteristics and long-term outcomes, including cardiac death, MACE (myocardial infarctio

SUBMITTER: Pereyra Pietri M 

PROVIDER: S-EPMC11948924 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature