Intestinal mucosal mitochondrial oxidative phosphorylation worsens with cirrhosis progression and is ameliorated with fecal microbiota transplantation.

ABSTRACT: Cirrhosis, the end-stage of liver disease, progresses through altered gut-liver axis and microbial change. Here we show that intestinal mucosal mitochondrial oxidative phosphorylation, which affects intestinal barrier worsens with cirrhosis progression. This is ameliorated with fecal microbiota transplantation.

SUBMITTER: Zeng J 

PROVIDER: S-EPMC11949008 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature