Frequency of dengue virus-specific T cells is related to infection outcome in endemic settings.

ABSTRACT: Dengue is widespread in tropical and subtropical regions globally and imposes a considerable disease burden. Annually, dengue virus (DENV) causes up to 400 million infections, of which approximately 25% present with clinical manifestations ranging from mild to fatal. Despite its significance as a growing public health concern, developing effective DENV vaccines has been challenging. One reason is the lack of comprehensive understanding of the influence exerted by prior DENV infections and immune responses with cross-reactive properties. To investigate this, we collected samples from a pediatric cohort study in dengue-endemic Managua, Nicaragua. We characterized T cell responses in 71 healthy children who had previously experienced 1 or more natural DENV infections and who, within 1 year af

SUBMITTER: Galvez RI 

PROVIDER: S-EPMC11949061 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature