A tailored graphene supramolecular gel for pharmaceutical crystallization.

ABSTRACT: A graphene-based supramolecular gel was designed and prepared to control the crystallization process and polymorphism of pharmaceuticals. The gelators were modified at the end segments with pyrene moieties, which spontaneously interact with the graphene surface by aromatic stacking interaction resulting in a graphene-incorporated supramolecular gel linked by noncovalent interactions between urea groups. When graphene was included into the gel, the critical gel concentration and system rigidity changed significantly, fluorescence spectroscopy determined the close π-π stacking interaction between the gelator and graphene, and the material was confirmed as a true nanocomposite gel system by electron microscopy. Further the graphene was oxidatively modified to obtain hydroxylated graphene (Gr-

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC11949076 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature