Transgelin 2 guards T cell lipid metabolism and antitumour function.

ABSTRACT: Mounting effective immunity against pathogens and tumours relies on the successful metabolic programming of T cells by extracellular fatty acids^1-3. Fatty-acid-binding protein 5 (FABP5) has a key role in this process by coordinating the efficient import and trafficking of lipids that fuel mitochondrial respiration to sustain the bioenergetic requirements of protective CD8⁺ T cells^4,5. However, the mechanisms that govern this immunometabolic axis remain unexplored. Here we report that the cytoskeletal organizer transgelin 2 (TAGLN2) is necessary for optimal fatty acid uptake, mitochondrial respiration and anticancer function in CD8⁺ T cells. TAGLN2 interacts with FABP5 to facilitate its cell surface localization and function in activated CD8⁺

SUBMITTER: Hwang SM 

PROVIDER: S-EPMC11949091 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature