Genome-Wide DNA Methylation and Copy Number Alterations in Gastrointestinal Stromal Tumors.

ABSTRACT: Gastrointestinal stromal tumors (GISTs) span a broad clinical spectrum, from indolent neoplasms to life-threatening metastatic tumors. A persistent limitation of current risk stratification systems is that a subset of GISTs is graded as low-risk but nevertheless metastasizes. Therefore, new predictive factors that improve risk stratification are needed. In this exploratory study, we investigated the potential of genome-wide DNA methylation profiling and copy number variation (CNV) analysis as additional prognostic tools for GISTs. We collected a cohort of 28 patients with GIST diagnosed between 2001 and 2022, with available follow-up and molecular data. This included 15 patients without progressive disease (seven low-risk and eight moderate- to high-risk GISTs) and 13 with progressive dise

SUBMITTER: Kleijn TG 

PROVIDER: S-EPMC11949093 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature