Distinct composition and metabolic potential of biliary microbiota in patients with malignant bile duct obstruction.

ABSTRACT:

Background

Emerging evidence highlights the role of biliary microbiota in hepato-biliary-pancreatic diseases. The characteristics of biliary microbiota in malignant bile duct obstruction remain poorly understood. This study aims to investigate the composition and metabolic functions of biliary microbiota in patients with malignant obstruction.

Methods

Eligible patients were enrolled in this prospective study at First Affiliated Hospital of Soochow University between December 2022 and October 2023, including distal cholangiocarcinoma, hilar cholangiocarcinoma, pancreatic ductal adenocarcinoma, periampullary carcinoma, and gallbladder carcinoma. The patients with choledocholithiasis served as controls. Bile samples were collected via endoscopic retrograde cholangiopancreatogra

SUBMITTER: Qian L 

PROVIDER: S-EPMC11949207 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature