Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice.

ABSTRACT: In humans and in animal models, susceptibility to arthritis is under complex genetic control, reflecting influences on the immunological processes that initiate autoimmunity and on subsequent inflammatory mechanisms in the joints. The effector phases are conveniently modeled by the K/BxN serum transfer system, a robust model well suited for genetic analysis where arthritis is initiated by pathogenic Ig. Here, we mapped the genetic loci distinguishing the high-responder BALB/c vs. low-responder SJL strains. After computational modeling of potential breeding schemes, we adapted a stepwise selective breeding strategy, with a whole-genome scan performed on a limited number of animals. Several genomic regions proved significantly associated with high sensitivity to arthritis. One of these regio

SUBMITTER: Ohmura K 

PROVIDER: S-EPMC1194932 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature