Cx40 Suppresses Sprouting Angiogenesis <i>In Vitro</i>.

ABSTRACT: Blood vessels are highly organized and form during development through a series of complex processes that include vasculogenesis, sprouting angiogenesis, and vessel remodeling. Several gap junction proteins (termed connexins, Cx)-including Cx40 (GJA5)-are expressed in vascular endothelium early during vessel development and are critical for establishment of a healthy vasculature. However, Cx40's specific role in regulating vessel growth remains uncertain: while previous studies have shown that developmental and cancer-associated neovascularization is reduced in Cx40-knockout mice, Cx40 knockout in zebrafish embryos enhances intersegmental vessel growth. Thus, in the current study, our aim was to identify Cx40's specific role in sprouting angiogenesis. First, we used a vessel-on-a-chip micr

SUBMITTER: Looker EK 

PROVIDER: S-EPMC11949415 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature