The kisspeptin analog C6 reverses reproductive dysfunction in a mouse model of hyperprolactinemia.

ABSTRACT:

In brief

Kisspeptin has been shown to be tightly associated with hyperprolactinemia. This study shows that similar to kisspeptin, its analog C6 produces a reversal of HPRL estrus cycle and ovulation disruption.

Abstract

HPRL, characterized by elevated prolactin levels, disrupts the hypothalamic-pituitary-gonadal axis, leading to reproductive dysfunctions such as menstrual irregularities, anovulation and infertility. Current treatments rely on dopamine agonists but are limited by side effects and resistance. Kisspeptin (Kp), a key neuropeptide regulating the reproductive function, offers potential as an alternative therapy. However, Kp's short half-life requires impractical administration regimens. To address this, we developed a synthetic Kp analog, C6, with enhanced pharmac

SUBMITTER: Beaudou C 

PROVIDER: S-EPMC11949517 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature