Nicotinic acid protects germinal vesicle oocyte meiosis against toxicity of benzo(a)pyrene in mice and humans.

ABSTRACT:

In brief

Low concentrations of benzo(a)pyrene in the follicular fluid of smokers disrupt oocyte maturation, leading to meiotic defects. Nicotinic acid (NA) partially rescues these defects, offering insights into potential strategies for protecting fertility.

Abstract

Benzo(a)pyrene (BaP), a carcinogen present in cigarette smoke, was detected in human follicular fluid at concentrations of approximately 5 nM in smokers and 7 nM in cases of assisted reproductive failure. However, whether a low concentration of BaP affects germinal vesicle (GV) oocyte maturation remains unclear. Here, we investigated the effects of 5 nM BaP on GV oocyte maturation in both mice and humans. In mice, GV oocytes were treated with 5 or 50 nM BaP, while human oocytes were exposed to 5 nM BaP. Our resu

SUBMITTER: Gao M 

PROVIDER: S-EPMC11949519 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature