Thalamocortical interactions reflecting the intensity of flicker light-induced visual hallucinatory phenomena.

ABSTRACT: Aberrant thalamocortical connectivity occurs together with visual hallucinations in various pathologies and drug-induced states, highlighting the need to better understand how thalamocortical interactions may contribute to hallucinatory phenomena. Flicker light stimulation (FLS) at 10-Hz reliably and selectively induces transient visual hallucinations in healthy participants. Arrhythmic flicker elicits fewer hallucinatory effects while delivering equal amounts of visual stimulation, together facilitating a well-controlled experimental setup to investigate the neural correlates of visual hallucinations driven by flicker rhythmicity. Using rhythmic and arrhythmic FLS during fMRI scanning, we found that rhythmic FLS elicited stronger activation in higher order visual cortices compared with ar

SUBMITTER: Amaya IA 

PROVIDER: S-EPMC11949548 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature