HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.

ABSTRACT: Hepatitis B virus (HBV) infections promote liver cancer initiation by inducing inflammation and cellular stress. Despite a primarily indirect effect on oncogenesis, HBV is associated with a recurrent genomic phenotype in hepatocellular carcinoma (HCC), suggesting that it impacts the biology of established HCC. Characterization of the interaction of HBV with host proteins and the mechanistic contributions of HBV to HCC initiation and maintenance could provide insights into HCC biology and uncover therapeutic vulnerabilities. In this study, we used affinity purification mass spectrometry to comprehensively map a network of 145 physical interactions between HBV and human proteins in HCC. A subset of the host factors targeted by HBV proteins were preferentially mutated in non-HBV-associated HC

SUBMITTER: Turnham RE 

PROVIDER: S-EPMC11949624 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature