Causal relationships between dietary factors and spinal diseases: a univariable and multivariable Mendelian randomization study.

ABSTRACT:

Background

Spinal diseases and their associated symptoms are prevalent across all age groups, and their incidence severely affects countless individuals' quality of life. The role of daily habits in the progression of these diseases is increasingly emphasized in research. Moreover, there are reports suggesting associations between dietary factors and the onset of spinal diseases. However, the exact causal relationship between dietary factors and spinal diseases has not been fully elucidated.

Methods

We obtained GWAS data on 16 dietary intake and 187 dietary likings from the UK Biobank, and GWAS data on 23 types of spinal disorders from FinnGen R10. The analysis of causal effects was conducted using the Inverse Variance Weighted (IVW) test, and to ensure robustness, MR-Egger,

SUBMITTER: Chen YQ 

PROVIDER: S-EPMC11949805 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature