The Quorum Sensing Regulated sRNA Lrs1 Is Involved in the Adaptation to Low Iron in Pseudomonas aeruginosa.

ABSTRACT: Iron is an essential nutrient for microbial growth. The opportunistic pathogen Pseudomonas aeruginosa can survive under diverse conditions, including iron-depleted environments with the aid of small non-coding RNAs (sRNAs). P. aeruginosa also uses three quorum sensing (QS) systems: Las, Rhl and Pqs, to coordinate virulence and infection establishment at the population level. The aim of this study is to investigate the role of the sRNA Lrs1, the gene of which is positioned within the promoter of the Pqs biosynthetic operon pqsABCDE. Transcriptomics and phenotypic assays indicate that Lrs1 downregulates the production of the siderophore pyochelin but not pyoverdine, and that lrs1 regulation itself is dependent on iron availability. Although Lrs1 has been implicated in a positive feedback loo

SUBMITTER: Panagiotopoulou D 

PROVIDER: S-EPMC11949849 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature