Polyclonal carbapenemase-producing <i>Escherichia coli</i> in Northern Italy: the emergence of NDM-7.

ABSTRACT: The spread of extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing Escherichia coli clones in humans, animals, and the environment is of great concern worldwide. In this study, we characterized four carbapenemase-producing E. coli (CP-Ec) isolated from human samples. Two isolates of ST401, rarely associated with carbapenemase and/or ESBL resistance genes, harbored blaKPC-3 and blaVIM-1 genes, respectively, and were genetically distant from each other. One CP-Ec isolate belonging to ST355, typically found in poultry and environmental sources and not associated with carbapenemases, was blaKPC-3 positive and showed a wide range of virulence genes. The last CP-Ec strain belonged to ST3564, previously described in livestock with a large virulom

SUBMITTER: Mattioni Marchetti V 

PROVIDER: S-EPMC11949906 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature