High-Density Lipoprotein Cholesterol Trajectories and Lung Function Decline: A Prospective Cohort Study.

ABSTRACT:

Purpose

Cholesterol regulation is essential to maintain pulmonary homeostasis. Studies suggest that increased high-density lipoprotein cholesterol (HDL-C) levels correlate with better lung function. However, the longitudinal association of HDL-C with lung function remains unknown. We aimed to analyze the long-term correlation of HDL-C with lung function decline in a population-based cohort study.

Methods

We included 7,652 participants from a prospective community-based cohort study in South Korea. Participants were categorized into five trajectory groups based on repeated HDL-C measurements. Generalized linear mixed models with random intercepts and slopes were used to examine the longitudinal relationship between HDL-C levels and lung function decline within these groups.

SUBMITTER: Yoo B 

PROVIDER: S-EPMC11950013 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature