The effect of rosacea on neurodegenerative and neuropsychiatric diseases: a two-sample Mendelian randomization study.

ABSTRACT: This study aimed to explore the potential causal relationships between rosacea and Parkinson's disease, Alzheimer's disease, anxiety disorders, and depression with MR analysis. Genetic data for rosacea and the four neurodegenerative and neuropsychiatric disorders were sourced from GWAS databases. After completing stringent quality control procedures, SNPs meeting significance thresholds were selected as IVs. Our primary statistical analysis was conducted by IVW approach. To investigate the robustness of results, heterogeneity tests, sensitivity analyses, and pleiotropy assessments were conducted. Reverse MR analyses were subsequently carried out to further substantiate the causal relationships. The present study discovered a positive correlation between rosacea and an elevated risk of depr

SUBMITTER: Hu X 

PROVIDER: S-EPMC11950073 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature