The immune mechanism of the mTOR/ACC1/CPT1A fatty acid oxidation signaling pathway in Hashimoto's thyroiditis.

ABSTRACT:

Background

Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease (AITD), which is distinguished by high thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TgAb). The differentiation of CD4⁺T cell subsets in patients with HT is imbalanced, with Treg cells decreased and Th17 cells abnormally activated. Fatty acid oxidation supports the differentiation of Th17 cells and induces inflammation, but the specific mechanism is still unknown. This study aimed to explore the role of fatty acid oxidation and its pathway in the pathogenesis of autoimmune thyroiditis and the immune mechanism.

Methods

In in vitro experiments, a total of 60 HT patients and 20 healthy controls were selected and their CD4⁺T cells were sorted by magnetic b

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11950109 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature